• Understanding the Impact of the Madden-Julian Oscillation and the North Atlantic Subtropical High on Atlantic Tropical Cyclone Variability 

  Campbell, Jacob

  Tropical cyclone (TC) frequencies in the Atlantic Ocean have multiple influences of variability. Two important ones at subseasonal timescale are the Madden-Julian Oscillation (MJO) and North Atlantic Subtropical High ...
• Systematic Review of Opiate Use Disorder in Connection to Social Salience Attribution 

  Abdelhalim, Aya

  Opiate Use Disorder (OUD) is an increasingly prevalent disorder in the United States as more individuals begin using opiates and experience addiction. A major hallmark of OUD include progressive erosion of social ties ...
• Characterization of Pullulanase (glgX/pulA) in Francisella novicida U112 Growth, Gene Expression, and Biofilm Formation 

  Tasseff, Morgan

  Francisella (F.) tularensis is a Gram-negative bacterium that causes the highly infectious human disease, tularemia. Within Francisella, like many other bacteria, polysaccharides play pivotal roles in many different pathways, ...
• Investigating PD-1/PD-L1 Checkpoint Inhibition as a Treatment for Platinum-Resistant Ovarian Cancer 

  Carter, Rachel (2022)

  Ovarian cancer is the deadliest cancer of the female reproductive system, with the majority of patients experiencing relapse on first-line platinum-based chemotherapies. Therefore, identifying potential targets for additional ...
• Studies of Optical and Photocatalytic Properties of Lanthanide-Doped Upconversion Nanoparticle-Based Hybrid Nanoplatforms 

  Evangelista, Andrew (2022)

  Lanthanide-doped upconversion nanoparticles have the ability to convert near-infrared incident light into higher-energy ultraviolet or visible light photons. From this, a great interest has recently arisen in utilizing a ...
• High Performance Computing Techniques for Metropolis Monte Carlo Simulations of Oxidized Polypyrrole 

  Helmick, Greg P (2022)

  The dissertation research aims to develop and improve the high performance computingtechniques related to the parallelization of the Metropolis Monte Carlo Method (MMC). The MMC is inherently serial due to its basic nature ...
• Mechanisms of Exosome-Autophagy Interplay in Host Response to the Cytoplasmic RNA Virus (Rift Valley Fever Virus) and Development of Promising Countermeasure Approaches 

  Olanrewaju, Adeyemi Anthony (2022)

  Rift Valley fever virus (RVFV) is from the Bunyaviridae family, genus Phlebovirus, and causes Rift Valley Fever (RVF) disease for which no licensed vaccines or effective therapies are available. RVF is an important emerging ...
• Deep Learning Model to Identify Somatic Driver Mutations in Cancer 

  Pirun, Mono (2022)

  Large-scale genome sequencing efforts have generated somatic mutation data across large cohorts of patients and many tumor types. This comprehensive collection of data has enabled a more complete understanding of the ...
• A Machine Learning and Networks Approach to Infer Disease Mechanisms 

  Kural, Kamil Can (2022)

  All biological problems, including cancer, mental disorders, rare diseases, and immunological disorders, are complex multisystem pathophysiological shifts facilitated by functional changes. Multiple points of origin and ...
• The Impact of Ocean Dynamics on Atlantic Sea Surface Temperature Variability 

  Gozdz, Olivia (2022)

  Internal variations of Atlantic sea surface temperature (SST) on decadal to multidecadal timescales have been linked to numerous climate phenomena with subsequent socioeconomic impacts, such as frequency and intensity of ...
• Study of Small RNA-Binding Molecules as Inhibitors of TAR-Tat Interaction and HIV-1 Proviral Transcription 

  Khatkar, Pooja (2022)

  The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR), a 59 nucleotide, non-coding, stem loop structure present in 5’ LTR of HIV-1 genome at 3 nucleotide UCU bulge to facilitate the ...
• A Secretory Form of Parkin-Independent Mitophagy Contributes to the Repertoire of Extracellular Vesicles Released Into the Tumor Interstitial Fluid in Vivo 

  Howard, Marissa Ashton (2022)

  Extracellular vesicles (EVs) released from healthy and diseased tissue interstitial fluid (IF) into the lymphatic drainage are poorly understood aspects of EV biology. EVs circulating in the lymph constitute an information ...
• Organic and Polymer Structure Engineering, Characterization, and Analysis for Alkali-Ion and Redox Flow Batteries 

  Holguin, Kathryn (2022)

  Lithium-ion batteries (LIBs) have been the leading source of energy storage devices for decades. Their usage and applications are immeasurable, spanning from portable electronics like phones and tablets to electric vehicles, ...
• EGR1 Upregulation During Encephalitic Viral Infections Contributes to Inflammation and Cell Death 

  Lehman, Caitlin Woodson (2022)

  Early growth response 1 (EGR1) is an immediate early gene and transcription factor previously found to be significantly upregulated in human astrocytoma cells infected with Venezuelan equine encephalitis virus (VEEV). Loss ...
• Wild Meat Consumption in the Northeastern Peruvian Amazon: Implications for Conservation and Sustainability 

  Briceño Huerta, Fiorella Andrea (2022)

  Hunting is one of the most critical drivers of animal population decline. Despite its significance, wild meat consumption in Amazonian cities is poorly understood. In Iquitos, the largest urban center of the Peruvian Amazon, ...
• On Obscured AGN Growth in Mid-IR Dual AGNs and Beyond 

  Pfeifle, Ryan (2022)

  In our current cosmological paradigm, galaxy mergers play an integral in the hierarchical growth in the Universe, while at the same time we now know that most major galaxies host supermassive black holes (SMBHs) at their ...
• Effects of Chimeric NMDA Receptor GluN2 Subunit Expression on Native NMDA Receptor Pools, Dendritic Morphology, and Synaptic Transmission in the Developing Hippocampus 

  Keith, Rachel E (2022)

  The N-methyl-d-aspartate receptor (NMDAR) affects postnatal development of the rodent hippocampus: after the third postnatal week, NMDAR subunit composition shifts from GluN2B to GluN2A, changing both the calcium conductance ...
• A Framework to Explore Spatio-Temporal Surveillance of Adverse Events For Post Market Approved Drugs & Vaccines 

  Askar, Ahmed Mohamed (2022)

  Discovering all drug and vaccine side effects during the development process is impos-sible. This dissertation aims to propose a framework in exploring spatiotemporal adverse event surveillance models by identifying adverse ...
• Exploring Urban Shrinkage via Computational Approaches: A Case Study of the City of Detroit 

  Jiang, Na (2022)

  While the world’s total urban population continues to grow, not all cities are witnessing such growth, some are actually shrinking. This shrinkage causes several problems to emerge including population loss, economic ...
• A Computational Based Approach Linking Spatial and Temporal Pattern Stiffness to Decreased Lung Function in Idiopathic Pulmonary Fibrosis 

  Sangobowale, John (2022)

  Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of unknown etiology that is characterized by the histopathological pattern of usual interstitial pneumonia. The pathogenic mechanisms that regulate the ...

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